| Locus | Rv0013 |
| Gene Symbol | trpG |
| Synonyms | |
| Gene Name | anthranilate synthase component II trpG |
| Closely Related Orthologs | anthranilate synthase component II |
| Location | M. tuberculosis H37Rv: Chromosome 1: 14914-15612 + |
| Length | Gene: 699 nt Protein: 232 aa |
| External Links | TubercuList TBSGC Protein Structure Information TARGET Gene Information Search Google Scholar |
| Protein Domains | View Gene Neighborhood with Protein Domains and Polymorphisms |
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| View Multiple Alignment of Diversity Strains for Rv0013 Show All SNPs in Diversity Strains for Rv0013 |
| Gene Expression Data | |
| Pathways | tryptophan biosynthesis |
| Reactions | EC# 4.1.3.27 - chorismate + L-glutamine = anthranilate + L-glutamate + pyruvate + H+ |
| COG Annotations | COG:E Amino acid transport and metabolism COG:H Coenzyme transport and metabolism |
| KEGG Annotations | KEGG:00400 Phenylalanine, tyrosine and tryptophan biosynthesis KEGG:00790 Folate biosynthesis KEGG:02020 Two-component system - General |
| Operons | Rv0012-trpG Operon |
TraSH Essentiality (see Sassetti et al., 2003) | Not Essential |
| Display Options | |
| Tools | |
L. Rickman, C. Scott et al.A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor.Mol. Microbiol.2005 curated sgi 2009-07-27 | Q. Gao, KE. Kripke et al.Gene expression diversity among Mycobacterium tuberculosis clinical isolates.Microbiology (Reading, Engl.)2005 curated sgi 2009-07-27 | R. Manganelli, MI. Voskuil et al.Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression.Mol. Microbiol.2002 curated sgi 2009-07-27 | X. Pang, P. Vu et al.Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis.Microbiology (Reading, Engl.)2007 curated sgi 2009-07-27 | Q. Gao, K. Kripke et al.Comparative expression studies of a complex phenotype: cord formation in Mycobacterium tuberculosis.Tuberculosis (Edinb)2004 curated sgi 2009-07-27 | GM. Rodriguez, MI. Voskuil et al.ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.Infect. Immun.2002 curated sgi 2009-07-28 | HD. Park, KM. Guinn et al.Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis.Mol. Microbiol.2003 curated sgi 2009-07-28 | HI. Boshoff, TG. Myers et al.The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action.J. Biol. Chem.2004 curated sgi 2009-07-28 | G. Rehren, S. Walters et al.Differential gene expression between Mycobacterium bovis and Mycobacterium tuberculosis.Tuberculosis (Edinb)2007 curated sgi 2009-07-28 | R. Manganelli, MI. Voskuil et al.The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages.Mol. Microbiol.2001 curated sgi 2009-07-27 | DR. Sherman, M. Voskuil et al.Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.Proc. Natl. Acad. Sci. U.S.A.2001 curated sgi 2009-07-28 | MI. Voskuil, KC. Visconti et al.Mycobacterium tuberculosis gene expression during adaptation to stationary phase and low-oxygen dormancy.Tuberculosis (Edinburgh, Scotland)2004 curated sgi 2009-07-28 | MI. Voskuil, D. Schnappinger et al.Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.J. Exp. Med.2003 curated sgi 2009-07-28 | RP. Morris, L. Nguyen et al.Ancestral antibiotic resistance in Mycobacterium tuberculosis.Proc. Natl. Acad. Sci. U.S.A.2005 curated sgi 2009-07-28 | TR. Rustad, MI. Harrell et al. The enduring hypoxic response of Mycobacterium tuberculosis. PLoS ONE 2008 PMID:18231589 curated sgi 2009-07-30 | N. Andreu & I. Gibert Cell population heterogeneity in Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) 2008 PMID:18502178 curated sgi 2009-07-30 | |
| Proteins | |
| Genomic Sequence | |