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    • M. tuberculosis H37Rv (GB): Rv2429 - alkyl hydroperoxide reductase D protein ahpD

    << Previous Gene on Contig (Rv2428 ) Next Gene on Contig (Rv2430c ) >>
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    5
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    19
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    1
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    6
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    Legend
    Protein Domains
    Gene Id : 7000000635255669
    Gene Info Collapse
    Locus Rv2429
    Gene Symbol ahpD
    Synonyms  
    Gene Name alkyl hydroperoxide reductase D protein ahpD  
    Closely Related Orthologs alkyl hydroperoxide reductase D protein ahpD ?
    Location M. tuberculosis H37Rv (GB): Chromosome 1: 2726806-2727339 +
    Length Gene: 534 nt
    Protein: 177 aa
    External Links TubercuList ?
    TARGET Gene Information ?
    Proteome 2D-PAGE Database - Search ?
    STRING Protein-Protein Interactions
    STITCH Chemical-Protein Interactions
    Search Google Scholar ?
    Protein Domains View Gene Neighborhood with Protein Domains and Polymorphisms
    Diversity Graph Collapse
     
    View Multiple Alignment of Diversity Strains for Rv2429
    Show All SNPs in Diversity Strains for Rv2429
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    Gene Expression Data
    Gene Profiles ?
    Samples And Conditions ?
    Genes with Correlated Expression
    Scatterplot of Gene Expression
    Protein Information Collapse
    Protein Structure View Protein Structure
    Functional Annotations Collapse
    Functional Annotations GO:0005515 ? protein binding
    Evidence Code - IPI: Inferred from Physical Interaction
    A. Koshkin, GM. Knudsen et al.
    Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis.
    GO:0005886 ? plasma membrane
    Evidence Code - IDA: Inferred from Direct Assay
    S. Gu,J. Chen,KM. Dobos,EM. Bradbury,JT. Belisle,X. Chen
    Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain.
    GO:0032843 ? hydroperoxide reductase activity
    Evidence Code - IDA: Inferred from Direct Assay
    PJ. Hillas, FS. del Alba et al.
    The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis.
    GO:0042803 ? protein homodimerization activity
    Evidence Code - IPI: Inferred from Physical Interaction
    PJ. Hillas, FS. del Alba et al.
    The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis.
    GO:0045454 ? cell redox homeostasis
    Evidence Code - IPI: Inferred from Physical Interaction
    R. Bryk, CD. Lima et al.
    Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
    GO:0070207 ? protein homotrimerization
    Evidence Code - IPI: Inferred from Physical Interaction
    R. Bryk, CD. Lima et al.
    Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
    COG Annotations COG:S ? Function unknown
    Operons ahpC-ahpD ? Operon
    TraSH Essentiality
    (see Sassetti et al., 2003)    		 Not Essential
    Tools Collapse
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    Curated Publications Collapse
    HI. Boshoff, TG. Myers et al. The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action. J. Biol. Chem. 2004 PMID:15247240
    promoted psisk 2009-06-10
    RP. Morris, L. Nguyen et al. Ancestral antibiotic resistance in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2005 PMID:16103351
    promoted psisk 2009-06-10
    GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002 PMID:12065475
    promoted psisk 2009-06-10
    X. Pang, P. Vu et al. Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Microbiology (Reading, Engl.) 2007 PMID:17379732
    promoted psisk 2009-06-10
    L. Rickman, C. Scott et al. A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor. Mol. Microbiol. 2005 PMID:15882420
    promoted psisk 2009-06-10
    Publications Awaiting Curatorial Review Collapse
    Q. Gao, KE. Kripke et al. Gene expression diversity among Mycobacterium tuberculosis clinical isolates. Microbiology (Reading, Engl.) 2005
    curated sgi 2009-07-27
    TR. Rustad, MI. Harrell et al. The enduring hypoxic response of Mycobacterium tuberculosis. PLoS ONE 2008
    curated sgi 2009-07-27
    R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
    curated sgi 2009-07-27
    Q. Gao, K. Kripke et al. Comparative expression studies of a complex phenotype: cord formation in Mycobacterium tuberculosis. Tuberculosis (Edinb) 2004
    curated sgi 2009-07-27
    MI. Voskuil, KC. Visconti et al. Mycobacterium tuberculosis gene expression during adaptation to stationary phase and low-oxygen dormancy. Tuberculosis (Edinburgh, Scotland) 2004
    curated sgi 2009-07-28
    MI. Voskuil, D. Schnappinger et al. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J. Exp. Med. 2003
    curated sgi 2009-07-28
    HD. Park, KM. Guinn et al. Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol. Microbiol. 2003
    curated sgi 2009-07-28
    G. Rehren, S. Walters et al. Differential gene expression between Mycobacterium bovis and Mycobacterium tuberculosis. Tuberculosis (Edinb) 2007
    curated sgi 2009-07-28
    N. Andreu & I. Gibert Cell population heterogeneity in Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) 2008
    curated sgi 2009-07-28
    R. Manganelli, MI. Voskuil et al. Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression. Mol. Microbiol. 2002 PMID:12123450
    curated sgi 2009-07-30
    TN. Farivar, PJ. Varnousfaderani et al. Mutation in alkylhydroperoxidase D gene dramatically decreases persistence of Mycobacterium bovis bacillus calmette-guerin in infected macrophage. Indian journal of medical sciences 2008 PMID:18688112
    active annot 2009-01-07
    T. Jaeger Peroxiredoxin systems in mycobacteria. Subcell. Biochem. 2007 PMID:18084895
    active annot 2009-01-07
    JJ. LeBlanc, RJ. Davidson et al. Compensatory functions of two alkyl hydroperoxide reductases in the oxidative defense system of Legionella pneumophila. J. Bacteriol. 2006 PMID:16923890
    active annot 2009-01-07
    S. Shi & S. Ehrt Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis. Infect. Immun. 2006 PMID:16368957
    active annot 2009-01-07
    BG. Guimarães, H. Souchon et al. Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. J. Biol. Chem. 2005 PMID:15886207
    active annot 2009-01-07
    A. Koshkin, XT. Zhou et al. Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress. Antimicrob. Agents Chemother. 2004 PMID:15215090
    active annot 2009-01-07
    A. Koshkin, GM. Knudsen et al. Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis. Arch. Biochem. Biophys. 2004 PMID:15178486
    active annot 2009-01-07
    T. Jaeger, H. Budde et al. Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis. Arch. Biochem. Biophys. 2004 PMID:14871480
    active annot 2009-01-07
    A. Koshkin, CM. Nunn et al. The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined by mutagenesis, crystallography, and kinetics. J. Biol. Chem. 2003 PMID:12761216
    active annot 2009-01-07
    CM. Nunn, S. Djordjevic et al. The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design. J. Biol. Chem. 2002 PMID:11914371
    active annot 2009-01-07
    R. Bryk, CD. Lima et al. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002 PMID:11799204
    active annot 2009-01-07
    I. Olsen, M. Tryland et al. AhpC, AhpD, and a secreted 14-kilodalton antigen from Mycobacterium avium subsp. paratuberculosis distinguish between paratuberculosis and bovine tuberculosis in an enzyme-linked immunosorbent assay. Clin. Diagn. Lab. Immunol. 2001 PMID:11427429
    active annot 2009-01-07
    PJ. Hillas, FS. del Alba et al. The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis. J. Biol. Chem. 2000 PMID:10766746
    active annot 2009-01-07
    I. Olsen, LJ. Reitan et al. Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis. Infect. Immun. 2000 PMID:10639449
    active annot 2009-01-07
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