Systems Biology
The Purpose of the TB Systems Biology Program
The Tuberculosis Systems Biology Program will experimentally map and computationally model the molecular pathways of M. tuberculosis under conditions relevant to TB pathogenesis. To do so, we have established a collaborative network that will perform systematic profiling using ChIP-Seq, transcriptomics, proteomics, glycomics, metabolomics, and lipidomics during both in vitro and in vivo growth and will integrate these data into predictive computational models of the M. tuberculosis regulatory and metabolic networks.
All data and software developed for this project will be made publicly available.
The Tuberculosis Systems Biology Program is one of four centers established by the National Institute of Allergy and Infectious Diseases (NIAID) to developSystems Biology Approaches to Infectious Disease.
For more information, see the TB Systems Biology Program web site.
Regulatory Network
View and search regulatory network inferred from ChIP-Seq experiments, and access underlying data
Metabolic Network
View and search metabolic pathways and overlay experimental data
Pathway-tools is the software that was used to generate and maintain TBDB Pathways.
It is available in both web-based and desktop forms, and provides a variety of tools for analyzing and visualizing metabolic and
regulatory networks.
The software is freely available for academics and can be found here.
Resources
View protocols, publications, software, and download data sets