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  • Rv3804c - secreted fibronectin-binding protein antigen fbpA


    Protein Domains

    Gene Information
    LocusRv3804c
    SymbolfbpA
    Gene Namesecreted fibronectin-binding protein antigen fbpA
    Location4265642 - 4266658 (-)
    SpeciesMycobacterium tuberculosis H37Rv complete genome.
    LengthGene:1017 bp
    Protein:339 aa
    External LinksTuberculist
    Target Gene Information
    String Protein-Protein Interactions
    STITCH Chemical-Protein Interactions
    Search Google Scholar
    Orthologs
    Orthogroup Number22785
    Related GenesMAP0216 MAV_0214 Mkms_5102 Mkms_5103 ML0097 ML0098 Mmcs_5014 Mmcs_5015 MSMEG_6396 MSMEG_6398 MSMEG_6399 MT3910 MT3911 MUL_4986 MUL_4987 Mvan_5644 Mvan_5645 nfa1810 nfa1820 nfa1830 Rv3803c
    Transcriptional Regulation
    Operons View gene in operon browser
    Regulatory Network
    Search for regulators of Rv3804c
    Gene Expression Gene Profiles
    Samples and Conditions
    Expression Correlation Genes with Correlated Expression
    Scatterplot of Gene Expression

    Sequence
    Proteins
    Genomic Sequence
    Community Annotations Pending Curatorial Review
    FieldValueStatusCreatorDate
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    authors,N. Matluk,JA. Rochira,A. Karaczyn,T. Adams,JM. Verdi A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    authors,G. Kumar,PK. Dagur,M. Singh,VS. Yadav,R. Dayal,HB. Singh,VM. Katoch,U. Sengupta,B. Joshi Diagnostic potential of Ag85C in comparison to various secretory antigens for childhood tuberculosis. Scand. J. Immunol. 2008
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    authors,E. Lozes,K. Huygen,J. Content,O. Denis,DL. Montgomery,AM. Yawman,P. Vandenbussche,JP. Van Vooren,A. Drowart,JB. Ulmer,MA. Liu Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 1997
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    authors,DR. Ronning,T. Klabunde,GS. Besra,VD. Vissa,JT. Belisle,JC. Sacchettini Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. 2000
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    authors,N. Matluk,JA. Rochira,A. Karaczyn,T. Adams,JM. Verdi A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    authors,G. Kumar,PK. Dagur,M. Singh,VS. Yadav,R. Dayal,HB. Singh,VM. Katoch,U. Sengupta,B. Joshi Diagnostic potential of Ag85C in comparison to various secretory antigens for childhood tuberculosis. Scand. J. Immunol. 2008
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    authors,E. Lozes,K. Huygen,J. Content,O. Denis,DL. Montgomery,AM. Yawman,P. Vandenbussche,JP. Van Vooren,A. Drowart,JB. Ulmer,MA. Liu Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 1997
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    authors,DR. Ronning,T. Klabunde,GS. Besra,VD. Vissa,JT. Belisle,JC. Sacchettini Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. 2000
    InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
    Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique.
    SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
    InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
    Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique.
    SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
    InteractionRegulatedBy Rv1221activeyamir.moreno2012-10-05
    Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
    R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
    Nameacyl CoA:diacylglycerol acyltransferaseactivemjackson2012-10-05
    Triglyceride biosynthesis
    Nameacyl CoA:diacylglycerol acyltransferaseactivemjackson2012-10-05
    Triglyceride biosynthesis
    Namemycolyltransferase 85A;INVOLVED IN CELL WALL MYCOLOYLATIONactivemjackson2012-10-05
    Mycolic acid processing
    Namemycolyltransferase 85A;INVOLVED IN CELL WALL MYCOLOYLATIONactivemjackson2012-10-05
    Mycolic acid processing
    SymbolAg85Aactivejlew2012-03-07
    Tat substrate. Demonstrated by experimental verification that four secreted proteins from Mtb carrying putative Tat signals are bona fide Tat substrates
    M. Marrichi, L. Camacho et al. Genetic Toggling of Alkaline Phosphatase Folding Reveals Signal Peptides for All Major Modes of Transport across the Inner Membrane of Bacteria. J. Biol. Chem. 2008
    TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactiveextern:JZUCKER2012-03-06
    Assay of protein purified to homogeneity from its native host
    authors,JT. Belisle,VD. Vissa,T. Sievert,K. Takayama,PJ. Brennan,GS. Besra Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997
    TermEC:2.3.1.122 Trehalose O-mycolyltransferase. - NRactiveextern:JZUCKER2012-03-06
    Assay of protein purified to homogeneity from its native host
    authors,JT. Belisle,VD. Vissa,T. Sievert,K. Takayama,PJ. Brennan,GS. Besra Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997
    TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactiveextern:JZUCKER2012-03-06
    Inferred from mutant phenotype
    V. Puech, C. Guilhot et al. Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis. Mol. Microbiol. 2002
    TermEC:2.3.1.122 Trehalose O-mycolyltransferase. - NRactiveextern:JZUCKER2012-03-06
    Inferred from mutant phenotype
    V. Puech, C. Guilhot et al. Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis. Mol. Microbiol. 2002
    OtherTBPWY:Triglyceride biosynthesisactivemjackson2012-03-05
    acyl CoA:diacylglycerol acyltransferase (mycobacterial recombinant strain phenotype; enzymatic)
    authors,AA. Elamin,M. Stehr,R. Spallek,M. Rohde,M. Singh The Mycobacterium tuberculosis Ag85A is a novel diacylglycerol acyltransferase involved in lipid body formation. Mol. Microbiol. 2011
    TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactivejjmcfadden2012-03-05
    Inferred from direct assay
    authors,DC. Crick,S. Mahapatra,PJ. Brennan Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacterium tuberculosis. Glycobiology 2001