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  • Rv3875 - 6 kda early secretory antigenic target esxA


    Protein Domains

    Gene Information
    LocusRv3875
    SymbolesxA
    Gene Name6 kda early secretory antigenic target esxA
    Location4352609 - 4352896 (+)
    SpeciesMycobacterium tuberculosis H37Rv complete genome.
    LengthGene:288 bp
    Protein:96 aa
    External LinksTuberculist
    Target Gene Information
    String Protein-Protein Interactions
    STITCH Chemical-Protein Interactions
    Search Google Scholar
    Orthologs
    Orthogroup Number13981
    Related GenesMkms_0080 ML0049 Mmcs_0071 MSMEG_0066 MT3989 Mvan_0079
    Transcriptional Regulation
    Operons View gene in operon browser
    Regulatory Network
    Search for regulators of Rv3875
    Gene Expression Gene Profiles
    Samples and Conditions
    Expression Correlation Genes with Correlated Expression
    Scatterplot of Gene Expression

    Sequence
    Proteins
    Genomic Sequence
    Community Annotations Pending Curatorial Review
    FieldValueStatusCreatorDate
    InteractionPhysicalInteraction Rv3874activeshahanup862012-10-05
    Affinity purification (Physical interaction)
    ML. Burts, WA. Williams et al. EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections. Proc. Natl. Acad. Sci. U.S.A. 2005
    InteractionPhysicalInteraction Rv3874activeshahanup862012-10-05
    Affinity purification (Physical interaction)
    LM. Okkels & P. Andersen Protein-protein interactions of proteins from the ESAT-6 family of Mycobacterium tuberculosis. J. Bacteriol. 2004
    InteractionRegulatory Rv3872activeshahanup862012-10-05
    Structural Analysis
    A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
    InteractionRegulatory Rv3872activeshahanup862012-10-05
    Structural Analysis
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionRegulatory Rv3872activeshahanup862012-10-05
    Structural Analysis
    PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
    InteractionRegulatory Rv3872activeshahanup862012-10-05
    Structural Analysis
    authors,PS. Renshaw,P. Panagiotidou,A. Whelan,SV. Gordon,RG. Hewinson,RA. Williamson,MD. Carr Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6*CFP-10 complex. Implications for pathogenesis and virulence. J. Biol. Chem. 2002
    InteractionRegulatory Rv3872activeshahanup862012-10-05
    Spectrophotometric
    A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
    InteractionRegulatory Rv3872activeshahanup862012-10-05
    Spectrophotometric
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionRegulatory Rv3872activeshahanup862012-10-05
    Spectrophotometric
    PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
    InteractionRegulatory Rv3872activeshahanup862012-10-05
    Spectrophotometric
    authors,PS. Renshaw,P. Panagiotidou,A. Whelan,SV. Gordon,RG. Hewinson,RA. Williamson,MD. Carr Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6*CFP-10 complex. Implications for pathogenesis and virulence. J. Biol. Chem. 2002
    InteractionPhysicalInteraction Rv3874activeshahanup862012-10-05
    Affinity purification (Physical interaction)
    ML. Burts, WA. Williams et al. EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections. Proc. Natl. Acad. Sci. U.S.A. 2005
    InteractionPhysicalInteraction Rv3874activeshahanup862012-10-05
    Affinity purification (Physical interaction)
    LM. Okkels & P. Andersen Protein-protein interactions of proteins from the ESAT-6 family of Mycobacterium tuberculosis. J. Bacteriol. 2004
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
    InteractionRegulatedBy Rv3414cactiveyamir.moreno2012-10-05
    One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. .
    M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
    InteractionRegulatedBy Rv2710activeyamir.moreno2012-10-05
    One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. .
    M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
    InteractionRegulatedBy Rv2021cactiveyamir.moreno2012-10-05
    One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. .
    M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
    InteractionRegulatedBy Rv1221activeyamir.moreno2012-10-05
    Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
    R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
    SymbolESAT-6activejlew2012-03-07
    Forms homodimer. Forms heterodimer with CFP-10.. Yeast two-hybrid to examine the interactions between ESX-1 proteins
    J. Teutschbein, G. Schumann et al. A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis. Microbiol. Res. 2007