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  • Rv3873 - PPE family protein


    Protein Domains

    Gene Information
    LocusRv3873
    SymbolPPE68
    Gene NamePPE family protein
    Location4351075 - 4352181 (+)
    SpeciesMycobacterium tuberculosis H37Rv complete genome.
    LengthGene:1107 bp
    Protein:369 aa
    External LinksTuberculist
    Target Gene Information
    String Protein-Protein Interactions
    STITCH Chemical-Protein Interactions
    Search Google Scholar
    Orthologs
    Orthogroup Number13738
    Related GenesML0051 MT3987
    Transcriptional Regulation
    Operons View gene in operon browser
    Regulatory Network
    Search for regulators of Rv3873
    Gene Expression Gene Profiles
    Samples and Conditions
    Expression Correlation Genes with Correlated Expression
    Scatterplot of Gene Expression

    Sequence
    Proteins
    Genomic Sequence
    Community Annotations Pending Curatorial Review
    FieldValueStatusCreatorDate
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
    InteractionPhysicalInteraction Rv3872activeshahanup862012-10-05
    Co-expression (Functional linkage)
    PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
    InteractionPhysicalInteraction Rv3868activeshahanup862012-10-05
    Co-expression (Functional linkage)
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionPhysicalInteraction Rv3868activeshahanup862012-10-05
    Co-expression (Functional linkage)
    A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
    InteractionPhysicalInteraction Rv3864activeshahanup862012-10-05
    Affinity purification (Physical interaction)
    authors,M. Sani,EN. Houben,J. Geurtsen,J. Pierson,K. de Punder,M. van Zon,B. Wever,SR. Piersma,CR. Jiménez,M. Daffé,BJ. Appelmelk,W. Bitter,N. van der Wel,PJ. Peters Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 2010
    InteractionPhysicalInteraction Rv3864activeshahanup862012-10-05
    Affinity purification (Physical interaction)
    P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
    InteractionPhysicalInteraction Rv3864activeshahanup862012-10-05
    Affinity purification (Physical interaction)
    P. Brodin, K. Eiglmeier et al. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 2002
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
    InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
    Co-expression (Functional linkage)
    J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
    InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
    Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
    J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006