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  • Rv1886c - secreted fibronectin-binding protein antigen 85-B fbpB


    Protein Domains

    Gene Information
    LocusRv1886c
    SymbolfbpB
    Gene Namesecreted fibronectin-binding protein antigen 85-B fbpB
    Location2134890 - 2135867 (-)
    SpeciesMycobacterium tuberculosis H37Rv complete genome.
    LengthGene:978 bp
    Protein:326 aa
    External LinksTuberculist
    Target Gene Information
    String Protein-Protein Interactions
    STITCH Chemical-Protein Interactions
    Search Google Scholar
    Orthologs
    Orthogroup Number21747
    Related GenesMAP1609c MAV_2816 Mkms_2817 ML2028 Mmcs_2773 MSMEG_3580 MT1934 MUL_2970 Mvan_3061
    Transcriptional Regulation
    Operons View gene in operon browser
    Regulatory Network
    Search for regulators of Rv1886c
    Gene Expression Gene Profiles
    Samples and Conditions
    Expression Correlation Genes with Correlated Expression
    Scatterplot of Gene Expression

    Sequence
    Proteins
    Genomic Sequence
    Community Annotations Pending Curatorial Review
    FieldValueStatusCreatorDate
    InteractionPhysicalInteraction Rv1911cactivekaveri.verma2012-10-05
    In vitro transposition reactions
    M. Braunstein,IV. Griffin TJ,JI. Kriakov,ST. Friedman,ND. Grindley,WR. Jacobs Identification of genes encoding exported Mycobacterium tuberculosis proteins using a Tn552'phoA in vitro transposition system. J. Bacteriol. 2000
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    authors,N. Matluk,JA. Rochira,A. Karaczyn,T. Adams,JM. Verdi A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    authors,G. Kumar,PK. Dagur,M. Singh,VS. Yadav,R. Dayal,HB. Singh,VM. Katoch,U. Sengupta,B. Joshi Diagnostic potential of Ag85C in comparison to various secretory antigens for childhood tuberculosis. Scand. J. Immunol. 2008
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    authors,E. Lozes,K. Huygen,J. Content,O. Denis,DL. Montgomery,AM. Yawman,P. Vandenbussche,JP. Van Vooren,A. Drowart,JB. Ulmer,MA. Liu Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 1997
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    structural analysis
    authors,DR. Ronning,T. Klabunde,GS. Besra,VD. Vissa,JT. Belisle,JC. Sacchettini Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. 2000
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    authors,N. Matluk,JA. Rochira,A. Karaczyn,T. Adams,JM. Verdi A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    authors,G. Kumar,PK. Dagur,M. Singh,VS. Yadav,R. Dayal,HB. Singh,VM. Katoch,U. Sengupta,B. Joshi Diagnostic potential of Ag85C in comparison to various secretory antigens for childhood tuberculosis. Scand. J. Immunol. 2008
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    authors,E. Lozes,K. Huygen,J. Content,O. Denis,DL. Montgomery,AM. Yawman,P. Vandenbussche,JP. Van Vooren,A. Drowart,JB. Ulmer,MA. Liu Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 1997
    InteractionPhysicalInteraction Rv0129cactiveprabhakarsmail2012-10-05
    Spectrophometric assay
    authors,DR. Ronning,T. Klabunde,GS. Besra,VD. Vissa,JT. Belisle,JC. Sacchettini Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. 2000
    InteractionRegulatedBy Rv0348activeyamir.moreno2012-10-05
    Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
    B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
    InteractionRegulatedBy Rv1221activeyamir.moreno2012-10-05
    Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
    R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
    Namemycolyltransferase 85B; INVOLVED IN CELL WALL MYCOLOYLATIONactivemjackson2012-10-05
    Mycolic acid processing
    Namemycolyltransferase 85B; INVOLVED IN CELL WALL MYCOLOYLATIONactivemjackson2012-10-05
    Mycolic acid processing
    TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactiveextern:JZUCKER2012-03-06
    Assay of protein purified to homogeneity from its native host
    authors,JT. Belisle,VD. Vissa,T. Sievert,K. Takayama,PJ. Brennan,GS. Besra Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997
    TermEC:2.3.1.122 Trehalose O-mycolyltransferase. - NRactiveextern:JZUCKER2012-03-06
    Assay of protein purified to homogeneity from its native host
    authors,JT. Belisle,VD. Vissa,T. Sievert,K. Takayama,PJ. Brennan,GS. Besra Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997
    TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactiveextern:JZUCKER2012-03-06
    Inferred from mutant phenotype
    V. Puech, C. Guilhot et al. Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis. Mol. Microbiol. 2002
    TermEC:2.3.1.122 Trehalose O-mycolyltransferase. - NRactiveextern:JZUCKER2012-03-06
    Inferred from mutant phenotype
    V. Puech, C. Guilhot et al. Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis. Mol. Microbiol. 2002
    TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactivejjmcfadden2012-03-05
    Inferred from direct assay
    authors,DC. Crick,S. Mahapatra,PJ. Brennan Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacterium tuberculosis. Glycobiology 2001